Hepatocellular Carcinoma and Cirrhosis of the Liver

 

 

Hepatocellular Carcinoma and Cirrhosis of the liver,tumour

There can be many serious consequences of cirrhosis of the liver. Hepatocellular carcinoma (HCC) is one serious complication that develops as a result of chronic cirrhosis. Some studies have shown that hepatocellular carcinoma is the main cause of death in those who develop a  chronic compensated cirrhosis. It is a common condition following cirrhosis and may occur 20 to 30 years after the initial damage  to the liver.

What is hepatocellular carcinoma?

Hepatocellular carcinoma is  primarily  a malignant condition of the liver cells. It is a very dangerous condition and may lead to death within 6 to 20 months after its onset. Although most cases occur in patients who have pre-existing cirrhosis, 25% of the patients may not even have a history or risk factors for the presence of cirrhosis.

The tumors that are present inside the liver are usually multi focal  (75%) hence it is difficult to remove them by surgery. As the disease progresses many metastases may form in the brain, lung, portal vein, bone or the lymph nodes around the portal region.

What causes hepatocellular carcinoma in cirrhosis of the liver?

There are a few causes and risk factors that may lead to the formation of liver cancer in patients in cirrhotic livers independent of the cause of cirrhosis. These include:

1. Hepatitis C virus (most common)
2. Hepatitis B virus
3. Older age
4. Race: it is more common in Asians of Japanese descent.
5. Male sex
6. Severity of compensated cirrhosis at presentation
7. Sustained activity of liver disease
8. Alcohol abuse especially in viral related cirrhosis
9. Hemochromatosis

Interventions such as  vaccinations against hepatitis and the slowing of alcoholic liver disease might decrease the incidence of hepatocellular carcinoma in the future. However because the latency period from the onset on injury to the development of cancer is so long, it may take many years till some substantial changes are observed in the patient.

Symptoms

The symptoms of patients suffering from liver cancer may resemble of an advancing case of cirrhosis of the liver. These include:

• Pruritis (body itching)
• Jaundice (yellow skin and sclera)
• Splenomegaly (enlargement of the spleen)
• Hepatomegaly (enlargement of the liver)
• Variceal bleeding
• Cachexia (body wasting)
• Abdominal enlargement
• Ascites (fluid in the abdominal cavity)
• Hepatic encephlopathy (mental disorientation, confusion or coma)
• Right upper abdominal pain (relatively uncommon symptom)
• Prominant veins
• Edema on the feet

Mortality/Morbidity

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Only 5% of  patients may be cured with  surgery. The median survival duration for HCC patientsliver cirrhosis,hepatocellular carcinoma,liver cancer is usually 6 months. The greater the extent of cirrhosis, the shorter is the patient survival time and the more limited  the therapeutic options . For example, if portal vein occlusion develops. the predicted survival may be even shorter.

Here is a list of a few complications which may arise from liver cancer:

• Hepatic failure
• Death from cachexia (body wasting)
• Variceal bleeding (stomach or esophagus)
• Tumor rupture
• Intra-peritoneal bleeding (within the body cavity)

Lab diagnosis

Hepatocellular carcinoma appears to be similar to cirrhosis of the liver with respect to its presentation of  symptoms and the risk factors involved. These laboratory tests may help recognize whether you are suffering from hepatocellular carcinoma:

• An elevated alpha fetoprotein (AFP) in the blood may hint at the presence of liver cancer in 75% of the patients. Prognosis of the condition is inversely linked to the level of AFP in the plasma. With co-existing signs such as  a growing liver mass, cirrhosis and an absence of acute hepatitis, a level of 1000ng/ml may be considered to be  presumptive evidence of cancer without confirming with a biopsy.

• Des-gamma-carboxy prothrombin (DCP) is another biomarker but it is not as effective as AFP.

• By using imaging studies such as liver ultrasound, CT or MRI, hepatocellular carcinoma can easily be seen.

• A liver biopsy is however, frequently necessary to confirm the diagnosis. There is a small risk of the tumor spread along the tract of the needle with this procedure. It may be omitted in the case of a growing cirrhotic mass (more than 2 cm) which has been positive on two consecutive imaging studies .

Treatment of Hepatocellular Carcinoma

The treatment options available vary depending on the size, location or the number of lesions. It may also be linked to the severity of underlying cirrhosis, presence of metastases or portal vein infiltration. Surgical resection or liver transplantation may offer some hope of a cure. Chemotherapy may offer hopes of palliation for untreatable cases of liver cancer developing in an individual with cirrhosis of the liver.

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